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ID 48397
FullText URL
Title Alternative
Usefulness of ICR mice as genetic resources
Author
Yamamoto, Yoshie
Uchio-Yamada, Kozue
Takano, Kaoru
Ogura, Atsuo
Asano, Toshihiko
Nakagawa, Masarou
Abstract
ICR(Yok:ICR)mice were introduced into the National Instltute of Infectious Diseases in 1965,and have been bred and produced there.Two inbred mutant mouse strains,MPS and ICGN,were created using(originated from)Yok:ICR mice in 1986.The MPS and ICGN mouse strains have served as the animal disease models of mycoplasma infectious disease and congenital nephritic syndrome,respectively. Genetic variations were detected by the genetic monitoring of Yok:ICR mice using biochemical markers.However, no difference was detected in gene expression profiles between the MPS and ICGN mouse strains.ICR mice may harbor genes that are spontaneously mutated,thereby allowing the creation of new pathological models through the segregation and/or selection(screening)of mutant genes.
Note
寄稿 (Contributions)
Published Date
2012-04
Publication Title
岡山実験動物研究会報
Publication Title Alternative
Proceedings of Okayama Association for Laboratory Animal Science
Volume
volume28
Publisher
岡山実験動物研究会
Publisher Alternative
Okayama Association for Laboratory Animal Science
Start Page
59
End Page
62
Content Type
Journal Article
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
poalas