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ID 47111
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Abstract
Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects.
Keywords
Graves' disease
human-TRAb
TSAb
Published Date
2011-06-25
Publication Title
岡山大学大学院教育学研究科研究集録
Publication Title Alternative
Bulletin of Graduate School of Education, Okayama University
Volume
volume147
Publisher
岡山大学大学院教育学研究科
Publisher Alternative
Graduate School of Education, Okayama University
Start Page
135
End Page
144
ISSN
1883-2423
NCID
AA12338258
Content Type
Departmental Bulletin Paper
language
英語
File Version
publisher
Refereed
False
Eprints Journal Name
bgeou