ID 45266
JaLCDOI
FullText URL
65_2_81.pdf 6.43 MB
Author
Sasaki, Motofumi
Okada, Shinichi
Miyamoto, Satoshi
Nishishita, Shingo
Usui Kataoka, Hitomi Kaken ID publons
Ogawa, Daisuke Kaken ID
Makino, Hirofumi
Abstract
Glomerular hyperfiltration is a common pathway leading to glomerulosclerosis in various kinds of kidney diseases. The 5/6 renal ablation is an established experimental animal model for glomerular hyperfiltration. On the other hand, low-grade inflammation is also a common mechanism for the progression of kidney diseases including diabetic nephropathy and atherosclerosis. Here we analyzed the gene expression profile in the remnant kidney tissues of 5/6 nephrectomized mice using a DNA microarray system and compared it with that of sham-operated control mice. The 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. DNA microarray analysis indicated the up-regulated expression of various kinds of genes related to the inflammatory process in remnant kidneys. We confirmed the up-regulated expression of platelet factor-4, and monocyte chemoattractant protein-1, 2, and 5 in remnant kidneys by RT-PCR. The current results suggest that the inflammatory process is involved in the progression of glomerulosclerosis and is a common pathway of the pathogenesis of kidney disease.
Keywords
kidney
inflammation
chemokine
Amo Type
Original Article
Published Date
2011-04
Publication Title
Acta Medica Okayama
Volume
volume65
Issue
issue2
Publisher
Okayama University Medical School
Start Page
81
End Page
89
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2011 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT