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ID 44291
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Title Alternative
Studies of Acetylcholine and Anticholinesterase The second Report. About the concentration-action curve of A. Ch.
Author
Okuda, Kazumasa
Abstract
The writer cxperimented the relation between the concentration and the action of A. Ch. on the eserinised rectus abdominis of frog, and the action of A. Ch. and atropine on the same, when both are present. The results are as follows. 1) The relation between the concentration of A. Ch. and the action produced can be expressed by the formula Kx = y/(100-y) where x concentration of A. Ch., y action produced, expressed as percent to the maximal possible action, and K constant. This relation suggests that a reversible monomolecular reaction occurs between A. Ch. and receptors either in the cell or on its surface. 2) This relation is not influenced by atropine. 3) The relation between the molar concentration of A. Ch. and Atropine on the eserinised abdominal rectus muscle of the frog is as follows. Concentration A. Ch. / (Concentration Atropine)(1.5) = Constant This formula shows that 1.5 molecules of atropine combine each receptor. After all the writer's results are similary as Clark's results. That is to say, cholinesterase has no effect upon the shape of the concentration-action curve.
Published Date
1941-12-31
Publication Title
岡山医学会雑誌
Volume
volume53
Issue
issue12
Publisher
岡山医学会
Start Page
2527
End Page
2533
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1889/53/12/53_12_2527/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma