このエントリーをはてなブックマークに追加
ID 43094
FullText URL
Thumnail 66_2477.pdf 2.2 MB
Title Alternative
STUDIES ON THE QUANTITATIVE DETERMINATION OF PROCAINE, AND SERUM PROCAINE-ESTERASE IN SURGICAL REGION Chapter III The Alteration of Procaine-Esterase Activity in Human Serum of Surgical Patients
Author
Tanino, Jyunzo
Abstract
Procaine hydrochloride 0.1mg was added to the fresh serum 1ml of a surgical patient. After it was kept in an artificial incubator (37°C) for 30 minutes exactly, the amount of non-hydrolyzed procain in it was determined by the method described above. The 1 ml of normal human serum perfectly hydrolyzed 0.1 mg. of procaine hydrochloride in 30 minutes. On the other hand it was recognized that the activity of serum procaine-esterase decreased in some cases of stomach cancer, gastric ulcer, cholecystitis, splenomegaly and so forth. The amount of non-hydrolyzed procaine in these diseases was less than 0.03mg. But it is not always proper to say that the lowering of its activity in serum 1 ml suggests that of the total serum procaine-esterase activity of the same individual. On observing the relationship between hematocrit value and the activity of procaine esterase, the degree of anemia was more or less proportional to the activity of procaine-esterase in serum 1 ml. Furthermore investigating the total volume of circulating blood-plasma at the same time, we obtained the results as follows in the cases of gastric cancer patients, in which the activity of procaineesterase decreased markedly, the plasma volume often increased more than that in normal man. Therefore, in the view-point of the esterase activities of the total circulating plasma volumes, there was little difference between these patients and normal individuals. On the other hand, observing the relation between the amount of serum protein and the activity of procaine-esterase, it was suggested that the more the former decreased, the lower the latter often became, but the both were not always parallel, and also that the lowering of the latter might be related to the derease of albumin content.
Published Date
1954-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume66
Issue
issue12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2477
End Page
2483
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/66/12/66_12_2477/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma