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ID 43092
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Title Alternative
STUDIES ON THE QUANTITATIVE DETERMINATION OF PROCAINE, AND SERUM PROCAINE-ESTERASE IN SURGICAL REGION Chapter I The Method of the Quanitative Determination of Procaine, and the Subsistence of Procaine-Esterase in Man
Author
Tanino, Jyunzo
Abstract
The method of the quantitative determination of procaine that has been adopted here is the colorimetric one which modified Brodie's; that is, in place of N (1-naphthyl) ethylendiamine in Brodie's method, more excellent Tsuda's reagent, 1-(ß-diethyl amino ethylamino) naphthalene dihydrochloride, has been used in ours, and buffer of boric acid (pH 9.0) has been used to separate procaine chemically from p-amino benzoic acid, hydrolyzed product of procaine produced by procainc-esterase in our method as well as in Brodie's. The procaine-esterase in 1 ml. of fresh human serum has the activity to he capable of hydrolyzing almost all the procaine hydrochloride 0.01 mg into p-amino benzoic acid and diethylamino ethanol in 4 to 5 minutes at shade temperature (10°C). The older the serum is in an ice stockroom, the more this activity of procaine-esterase in serum decreases. Procaine-esterase is scarcely existing in blood-corpuscles and extracellular fluid, such as fluid in bulla by burns or pleural exudation. Futhermore it is said that the narcotic action of diethylamino ethanol produced by the hydrolysis of procaine is weaker than that of procaine. Therefore it is more suitable for procaine to be used as local anesthesia than intravenous one.
Published Date
1954-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume66
Issue
issue12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
2461
End Page
2468
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/66/12/66_12_2461/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma