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ID 42978
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Thumnail 66_1091.pdf 5.67 MB
Title Alternative
Studies on Hereditary Nervous Diseases Part I. On Huntington's Chorea
Author
Ocho, Yakichi
Abstract
From my investigations of five families subject to Huntington's Chorea, I have come to the following conclusions. 1. Two of them are considered as double phenotypes of chorea and schizophrenia. Others remind us of double phenotypes of ptosis and the so-called lethal factors. 2. Four families are found to be subject to dementia and psychopathia as much as to choreatic movement; one family is liable only to psychopathia. Two families have a tendency to attempt suicide, commit murder and other crimes. 3. A case of anatomical examination shows a remarkable change in the cerebellar cortex, dentatum and nucleus olivalis, in spite of the slight change in striatum and cerebral cortex. Cases of change in nucleus olivaris may perhaps be rare. 4. Such "Disease Gene" as chorea Huntingtoni or "Lethal Factor", I suppose, is caused by the degradation or loss of functions of "Normal Gene" through mutation. Can it not be reasoned, then, that the very existence of "Disease Gene" brings the functions of "Normal Gene" into relief?
Published Date
1954-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume66
Issue
issue6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1091
End Page
1106
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/66/6/66_6_1091/_article/-char/ja/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma