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ID 42973
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Title Alternative
Studies on Synthetic Anthelmintics Part 3. Anthelmintic Studies on Alkylresorcinols and Alkylchlororesorcinols
Author
Ashikaga, Mitsuaki
Abstract
1. Anthelmintic effect in vitro against human and hog ascaris was examined with a total of 27 kinds of 4-alkyl-, 4-alkyl-6-chloro-, 4-alkyl-6-bromo-, and 4-alkyl-2, 6-dichloro-resorcinols in 1:1,000 to 1 2,000 dilutions. Based on the results thereby obtained, 14 kinds of compounds of alkylresorcinol and alkylmonochlororesorcinol series were submitted to anthelmintic treatment in man and their effect was examined by the egg-counting and worm-counting methods. 2. The in vitro effect of alkylresorcinols and their monochloro derivatives was found to be the strongest in hexylresorcinol and became weaker with a larger or smaller number of carbon atoms in the alkyl group. Comparison of the corresponding compounds showed that the alkylresorcinols generally possessed a stronger action than their monochloro derivatives. 3. Anthelmintic effect of alkylrescrcinols in man was also the strongest in the hexyl compound, followed by amyl- and heptyl-resorcinols. In the monochloro derivatives, their anthelmintic effect did not follow the order of their in vitro effect, effect, stronger than hexylresorcinol (m. p. 68-69°) being shown by amyl-(m. p. 43-44°), hexyl-(m. p. 46-48°), heptyl-(m. p. 45-47°), and octyl-chlororesorcinols (m. p. 49-51.5°), as well as by cyclo-hexylchororesorcinol (m. p. 86-88°), whose non-chlorinated compound was totally ineffective. 4. Ascaridical effect of alkylresorcinols decreased by the introduction of one bromine or two chlorine atoms.
Published Date
1954-05-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume66
Issue
issue5
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
985
End Page
993
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/66/5/66_5_985/_article/-char/ja/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma