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Title Alternative
Studies on the Neutralization Test of Rickettsia tsutsugamushi II: Studies on the Procedures of Neutralization Test of R. Tsutsugamushi
Author
Namba, Tomisaburo
Abstract
The author reinvestigated the procedures of neutralization test of Rickettsia tsutsugamushi in regard to the contact period of the agent with immune sera. At the same time, the "Absaettigungsversuch" (Wildfuehr) was also tried on R. tsutsugamushi. Mitani strain of R. tsutsugamushi isolated from the patients of Umayado disease in Kagawa prefecture was used as the test agent. The results were as follows: 1) In test tubes, R. tsutsugamushi combines with its antisera in a short time, and the virulence of R. tsutsugamushi falled along with prolongation of contact period. These facts suggest that estimation of the true titer of neutralization antibody become possible by the short-period-contact which causes no noticeable fall of rickettsial virulence. 2) In the neutralization test of R. tsutsugamushi, dilution of antisera to be mixed with rickettsiae in test tubes deteriorates its result, and addition of human or guinea-pig sera had no influence on its neutralizing effect. 3) No noticeable result was obtained in application of the "Absaettigungsversuch" to R. tsutsugamushi.
Published Date
1957-12-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
3117
End Page
3125
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/12/69_12_3117/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma