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ID 42587
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Title Alternative
Studies on the Protein Metabolism of the Explanted Bone Marrow Culture in Rabbits Part One Protein Metabolism of the Rabbit Bone Marrow, and Effects of Various Drugs on it
Author
Fujii, Yukio
Abstract
By carrying out a series of observations on the protein metabolism by bone marrow culture (Carrel flask method) and on the effect of various drugs acting directly on the bone marrow, the following results have been obtained: (1) Albumin is utilized for multiplication of the bone marrow tissue while globulin is produced by the bone marrow. Consequently, the increase of globulin has a correlation with marrow functions in direct proportion. (2) In globulin fractions, γ-globulin seems to play the most important rôle. (3) Both α- and β-globulins seem to play no important rôle. (4) Fibrinogen is produced by the bone marrow, and it has a close relationship with marrow functions. (5) Folic acid, vitamin B12, and bone marrow extract directly stimulate marrow functions, and they promote the production of globulin, especially of γ-globulin and fibrinogen on one hand, and the consumption of albumin on the other hand. (6) Nitromin (Nitrogen mustard-N-oxyde) lowers functions of the bone marrow and inhibits the production of globulin, paricularly γ-globulin and fibrinogen, and the consumption of albumin.
Published Date
1957-07-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue7
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1669
End Page
1684
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/7/69_7_1669/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma