このエントリーをはてなブックマークに追加
ID 42541
FullText URL
Thumnail 69_1135.pdf 3.38 MB
Title Alternative
EXPERIMENTAL STUDIES ON CHRONIC FLUORINE POISONING Part I. On development of poisoning, levels of serum calcium and of inorganic phosphor and changes in various organs
Author
Sakaguchi, Isao
Abstract
Bone changes in residents in the high fluorine zone, which were described by Prof. Dr. Hamamoto, called general attention in the medical world. This study was made based on clinical experiences that sclerotic changes of vertebrae found in patients complaining of lumbago were possibly caused by taking water from well which contained abnormally high concentration of fluorine. 1) Slight degree of mottled teeth and weight loss, averaging 20 gms, were found in rats fed on water containing 13 p. p. m. fluorine for one year. Bone changes, however, were not noticed and no changes were found in levels of serum calcium and inorganic phosphor. 2) Marked mottled teeth developed in rats fed on water containing 100 p. p. m. fluorine for same period, though general condition were not involved. Upper incisor overgrew, though fragile. No marked changes were found in skeletal system and level of serum calcium. Slight increase in serum inorganic phosphor was noticed with concomitant degeneration of renal parenchym suggesting close relation between them. Slight parenchymal degeneration were found in liver, heart, lung, spleen and other organs.
Published Date
1957-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume69
Issue
issue4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1135
End Page
1147
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/69/4/69_4_1135/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
Copyright© 岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma