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ID 41070
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Title Alternative
Influences of Various Non-Essential Amino Acids on the Hematopoiesis Part 3. Influences of hydroxyproline on the erythropoiesis and application of this substance in hypoplastic anemia
Author
Lee, Bin Zen
Abstract
The author studied influences of hydroxyproline on erythropoiesis by means of rabbit bone-marrow tissue culture and also used this substance in the treatment of hypoplastic anemia; and obtained the following results. 1. In loading hydroxyproline directly to rabbit bone marrow tissue culture(fluid medium), no significant change can be recognized in the number of erythrocytes and reticulocytes. As for the change in hemoglobin (Hb) content with addition of this substance, Hb decreases in the control whereas it increases slightly when added in a high concentration. 2. In the tissue culture of the bone marrow (cover slip method) obtained from sternum of 5 cases of hypoplastic anemia loaded with hydroxyproline, the tissue growth has been accelerated in three cases. The two unaffected cases turned out to be of panmyelophthisis type. 3. Of 5 cases with hypoplastic anemia to three cases daily intravenous injection of 150-300 mg hydroxyproline was given. As the result all of them showed an increase the leucocyte count, but the erythrocyte count and Hb increased only in one case and it proved to be ineffective in other two cases.
Published Date
1959-08-15
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue8-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
5087
End Page
5099
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/8-2/71_8-2_5087/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma