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ID 40994
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Title Alternative
Influences of Toxins of Salmonella Typhi, Salmonella Paratyphi A, B and Escherichia Coli on Bone-Marrow Tissue Culture Part 3. Influences of toxins of S. typhi, S. paratyphi A, B, and E. coli on the megakaryocyte functions of the guinea-pig bone marrow
Author
Motokura, Kiyoshi
Abstract
By the addition of toxins of S. typhi, S. paratyphi A, B, and E coli to the bone-marrow tissue culture of guinea pigs the author pursued the influences of these toxins on the functions of megakaryocytes, and obtained the following results. In the case of the toxins of S. typhi and S. typhi and S. paratypbi A, the appearance of vigorous platelet separation is markedly limited, indicating a marked decrease in the megakaryocyte functions of the bone marrow loaded with these toxins. On the other hand, in the case of addition of the toxin of S. paratyphi B the decrease in the megakaryocyte function is slight, whereas the toxin of E. coli brings about no fall in the megakaryocyte function but rather accelerates it slightly. From these findings it is believed that direct inhibitory action of these toxins on the megakaryocytes constitutes one of the important factors in the mechanism of thrombocytopenia in typhoid fever.
Published Date
1959-07-10
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume71
Issue
issue7-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
4249
End Page
4256
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/71/7-2/71_7-2_4249/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma