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ID 40769
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Title Alternative
Effect of prostaglandin E(1) and prostaglandin F(2α) on bone formation of cultured chick embryonic bone with special reference to the alkaline phosphatase activity
Author
Ueda, Shigeki
Abstract
The effects of prostaglandin E(1) (PGE(1)) and prostaglandin F(2α) (PGF(2α)) on bone formation were investigated with femur and tibia from 10-day chick embryo. When the bones were cultured in serum free medium, PGE(1) (10nM) caused a significant increase of bone alkaline phosphatase activity and a slight increase in bone protein content, whereas PGF(2α) (100nM) significantly decreased the enzyme activity. On the other hand, in a medium containing 20% serum, PGE1 did not affect the enzyme activity at 10nM, but slightly increased the activity at 1nM. No effect of PGE(1) on bone calcium content was observed in a concentration ranging from 0.1nM to 100nM. Thus, PGE1 was likely to stimulate bone formation at 10nM, whereas PGF(2α) supressed formation at 100nM.
Keywords
組織培養
プロスタグランディン
骨形成
Published Date
1989-08-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume101
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
763
End Page
770
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/101/7-8/101_7-8_763/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma