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ID 40432
Sort Key
10
FullText URL
Title Alternative
MEDICAL STUDIES ON CHONDROITlN SULFATE (IV) DISTRIBUTION OF CHONDROITIN SULFATE LABELED WITH S(35) IN ANIMAL BODY
Author
Kishida, Senzo
Abstract
0.1 ml. of the 1% solution of chondroitin sulfate labeled with S(35) was administered to mice intraperitoneally or 0.5 ml. was given per orally with gastric tube to another gronp of mice. Each two mice were killed every one, two, six, twelve, twenty four and fouty eight hours after the injection respectively and after a series of daily injection for a week samples of blood, lungs, heart, liver, kidneys, skin, muscles bones, spleen, brain, stomach and ntestines were taken from these animals. Radioactivity of S(35) was measured by BaSO(4) method using Lanritsen's electroscope. 1) The highest activity in blood was observed by about two hours after the injection, while in per oral administration it was reached after six hours. absorption of perorally administered chondroitin sulfate was estimated to reach roughly 35% abter 6 hours. 2) The excretion of labeled chondroitin sulfate seemed to be done from kidneys. The greater part was excreted in six hours and then the decrease in the activity of kidneys became slower. 3) Muscles and skin showed a considerable activity in 1-2 hours. A marked decrease was seen after six hours, then their activity seemed to remain unchanged. 4) Radioactivity of skeleton rose gradually, reached its maximum in twelve hours, and then had a tendency to show constant value. 5) In liver, spleen and brain highest activity was observed two hours after the injection.
Note
正誤表あり
Published Date
1953-09
Publication Title
岡山大学温泉研究所報告
Publication Title Alternative
Papers of the Institute for Thermal Spring Research, Okayama University
Volume
volume12
Publisher
岡山大学温泉研究所
Publisher Alternative
Institute for Thermal Spring Research, Okayama University
Start Page
42
End Page
51
ISSN
0369-7142
NCID
AN00032853
Content Type
Departmental Bulletin Paper
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/40422
language
日本語
OAI-PMH Set
岡山大学
File Version
publisher
Refereed
False
Eprints Journal Name
mmc