ID 40129
JaLCDOI
FullText URL
Thumnail 64_4_219.pdf 1.62 MB
Author
Doi, Maho
Nagamachi, Tomoko
Shinomiya, Kazuaki
Gomita, Yutaka
Abstract
We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells. The administration of imipramine or lithium alone for 14 days had no effect in saline-treated rats. The effect of ACTH was blocked by the administration of imipramine. Furthermore, the coadministration of imipramine and lithium for 14 days significantly increased the number of Ki-67-positive cells in both the saline and ACTH-treated rats. The coadministration of imipramine and lithium normalized the cell proliferation in the dentate gyrus of the hippocampus in rats treated with ACTH.
Keywords
ACTH
imipramine
lithium
proliferation
Ki-67
Amo Type
Original Article
Published Date
2010-08
Publication Title
Acta Medica Okayama
Volume
volume64
Issue
issue4
Publisher
Okayama University Medical School
Start Page
219
End Page
223
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT