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ID 3601
Eprint ID
3601
FullText URL
Thumnail O001732.pdf 371 KB
Title Alternative
肝疾患で減少した血漿フィブロネクチンは肝組織の線維化,炎症及び壊死の程度に相関した
Author
Jitoku, Michihiro
Abstract
We applied a modified enzyme-linked immunosorbent assay (ELISA) for the measurement of human plasma fibronectin and determined the level of plasma fibronectin in 90 patients with various liver diseases and 10 normal subjects. Diagnoses were made by liver biopsy under peritoneoscopy. Plasma fibronectin was significantly decreased in liver cirrhosis patients, but not in acute hepatitis or chronic hepatitis patients. Decreased plasma fibronectin was correlated poorly with 18 laboratory tests, including liver function tests, and inflammatory marker determinations performed prior to peritoneoscopy. A correlation was found between the decreased plasma fibronectin and the severity of fibrotic, inflammatory and necrotic changes of the liver. These results suggested that the level of plasma fibronectin may reflect the severity of tissue injury resulting from chronic liver diseases.
Keywords
plasma fibronectin
liver diseases
liver biopsy
Note
掲載順位 130 ; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3766203&dopt=Abstract
Published Date
1986-12-31
Publication Title
Content Type
Thesis or Dissertation
Grant Number
乙第1732号
Granted Date
1986-12-31
Thesis Type
Doctor of Philosophy in Medical Science
Grantor
岡山大学
Official Url
http://escholarship.lib.okayama-u.ac.jp/cgi/viewcontent.cgi?article=1985&context=amo
language
日本語
File Version
none
Refereed
Unknown