ID 32849
JaLCDOI
FullText URL
Author
Kawaura, Akihiko
Tanida, Noritoshi
Kamitani, Masato
Akiyama, Junichi
Mizutani, Masatoshi
Tsugawa, Naoko
Okano, Toshio
Takeda, Eiji
Abstract

We examined the effect of leg hyperthermia on oxidative stress in bedridden subjects with type 2 diabetes mellitus using 15-min sessions of far infrared rays over a two-week period. Four subjects (male 1, female 3) incapacitated by a stroke were recruited for this study. All patients were admitted to Takahashi Central Hospital and ate the same hospital meals. Fasting plasma glucose, HbA1c, tumor necrosis factor (TNF)alpha, free fatty acid, leptin, adiponectin and plasma 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) levels as a marker of oxidative stress were measured on admission, just before and 2 weeks after local heating of the leg. Results showed that plasma total 8-epi-PGF2alpha levels were decreased significantly while TNFalpha levels were increased significantly. On the other hand, glucose, HbA1c, free fatty acid, leptin and adiponectin levels were not changed during the study period. These results suggest that repeated leg hyperthermia may protect against oxidative stress.

Keywords
type 2 diabetes mellitus
leg hyperthermia
oxidative stress
8-epi-prostaglandin F2?
Amo Type
Case Report
Published Date
2010-04
Publication Title
Acta Medica Okayama
Volume
volume64
Issue
issue2
Publisher
Okayama University Medical School
Start Page
143
End Page
147
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT