ID 32660
JaLCDOI
FullText URL
Author
Takahashi, Michiko
Yamada, Gotaro
Miyamoto, Rieko
Doi, Toshihiko
Endo, Hisashi
Nishimoto, Hiroshi
Fujiki, Shigeatsu
Shimomura, Hiroyuki
Mizuno, Motowo
Tsuji, Takao
Abstract

We measured hepatitis C virus antibody titers in 13 patients with chronic hepatitis C to determine whether titration of hepatitis C virus antibody was useful or not, to predict and evaluate the efficacy of interferon (IFN) treatment. During administration of IFN, hepatitis C virus titers declined in all patients. Antibody titers performed before treatment as well as just at the end of treatment did not correlate with change of the alanine aminotransferase levels during administration of IFN. Antibody titers declined continuously after treatment in 5 patients with normal alanine amino-transferase levels for over 6 months after discontinuation of IFN. Antibody titers rose again in 6 patients whose alanine aminotransferase levels fluctuated after treatment. An exceptional pattern of change occurred in 2 patients whose antibody titers declined continuously although their alanine aminotransferase levels fluctuated after treatment. Repeated titration of hepatitis C virus antibody appears to be useful for evaluating the long-term efficacy of IFN treatment.

Keywords
titiration of hepatitis C virus antibody
interferon
chronic hepatitis C
efficacy of treatment
Amo Type
Article
Published Date
1992-10
Publication Title
Acta Medica Okayama
Volume
volume46
Issue
issue5
Publisher
Okayama University Medical School
Start Page
331
End Page
336
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT