ID 30979
JaLCDOI
FullText URL
Author
Imatoh, Takuya
Miyazaki, Motonobu
Momose, Yoshito
Uryu, Yoko
Tanihara, Shinichi
Une, Hiroshi
Abstract

Leptin is a hormone which is predominantly secreted by adipose tissue. Recent studies have shown that leptin increases arterial blood pressure. Although data from available animal studies clearly indicate an association between leptin and hypertension, results of human studies have been less definitive. We conducted a case-control study to examine the association between serum leptin levels and hypertension in 111 hypertensive subjects and 222 male controls, using conditional logistic regression analyses. Mean serum leptin levels were found to be marginally higher in the case subjects than in the control subjects (3.3 ng/ml versus 3.0 ng/ml), however, conditional logistic regression analysis revealed that subjects in the highest quartile had a significantly increased risk of hypertension compared with those in the lowest quartile, even after adjusting for drinking status and diabetes mellitus (adjusted OR, 2.11;95% CI, 1.01-4.39). Our findings suggest that leptin plays an important role in the development of hypertension.

Keywords
epidemiological study
hyperleptinemia
hypertension
leptin
Amo Type
Original Article
Published Date
2008-06
Publication Title
Acta Medica Okayama
Volume
volume62
Issue
issue3
Publisher
Okayama University Medical School
Start Page
169
End Page
174
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT