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ID 19805
Eprint ID
19805
FullText URL
Title Alternative
Clinical studies on bronchial asthma induced by chironomid midges -comparison between positive and negative cases to house dust-
Author
Kitani, Hikaru
Araki, Hiroyuki
Sudo, Michiyasu
Tanizaki, Yoshiro
Tada, Sinya
Kimura, Ikuro
Matsuoka, Hiroyuki
Ishii, Akira
Abstract
近年ユスリカが気管支喘息の原因抗原となり得ることが報告されている。しかし,その臨床的特徴はいまだ明らかにされていない。このユスリカ抗原の特徴を検討する目的で,気管支喘息症例163例をHD(ハウスダスト)に感作されたRAST score2+以上の陽性例82例とscore1+以下の陰性例81例とに分けて比較検討を行なった。その結果皮膚反応,ヒスタミン遊離,CTT抗原を用いた特異的IgE抗体いずれの検討においても,HDに感作された症例が,よりユスリカ抗原にも感作されやすいことが明らかになった。
Abstract Alternative
In recent years it has been reported that chironomid migdes might be one of the causative allergens in bronchial asthma. In order to clarify the clinical characteristics of bronchial asthma induced by chironomid midges (Tokunagayusurika akamusi), 163 patients with bronchial asthma were studied. The subjects were divided into two groups ; cases with negative (0~1 + ) and positive (2 + or more) RAST score to house dust. 1. Skin reaction to midges was positive in 54 cases (33.1%) out of 163 patients with bronchial asthma. Thirty-six cases (43.9%) out of 82 asthmatics with positive RAST score to house dust showed positive skin reaction to midges, but in 81 cases with negative RAST score, only 18 cases (22.2%) showed positive skin reaction. 2. Fourteen cases out of 85 asthmatics showed a significant amount of histamine release (more than 15%). A significant amount of histamine release was observed in 12 cases (23.5%) out of 51 cases with positive RAST score, but in only two cases (5.9%) out of 24 cases with negative RAST score. 3. Specific IgE antibodies to CTT (Chiromonus thummi thummi) was positive in 12 cases (18.2%) out of 66 asthmatics. In 41 asthmatics with positive RAST score to house dust, 12 cases (29.3%) showed positive RAST score to CTT, though in 25 cases with negative RAST score to house dust no cases showed positive RAST score to CTT. In conclusion, cases with house dust allergy were more easily sensitized by chironomid migdes than those cases without house dust allergy.
Keywords
気管支喘息 (Bronchial asthma)
ユスリカ (Chironomid midges)
ヒスタミン遊離 (Histamine release)
ハウスダスト (House dust)
Published Date
1989-07
Publication Title
環境病態研報告
Publication Title Alternative
Papers of the Institute for Environmental Medicine, Okayama University Medical Scool
Volume
volume60
Publisher
岡山大学医学部附属環境病態研究施設, 岡山大学医学部附属病院三朝分院
Publisher Alternative
Institute for Environmental Medicine, Okayama University Medical Scool
Start Page
54
End Page
60
ISSN
09133771
NCID
AN10084718
Content Type
Departmental Bulletin Paper
language
日本語
OAI-PMH Set
岡山大学
File Version
publisher
Refereed
False
Sort Key
11
Eprints Journal Name
mmc