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ID 19769
Eprint ID
19769
FullText URL
Title Alternative
Allergic reactions for severe intractable asthma and spa therapy
Author
Tanizaki, Yoshiro
Abstract
予後良好と言われる気管支喘息が,どのような反応系により重症難治化傾向を取るのか,そして温泉療法がどのように作用するのかについて,若干の検討を加えた。まず関与する反応系は,その惹起相,反応相(液性因子相,細胞性因子相)の組合せにより,代表的な3つの反応系に分類することができる。1)IgE-肥満細胞(惹起相);ヒスタミン(ロイコトリエン)(液性因子相);リンパ球,好塩基球,好酸球(細胞性因子相),2)IgG-好中球;ロイコトリエン;好中球,リンパ球,マクロファージ,3)非IgE系反応;PAF;好酸球,3')非IgE系反応;ロイコトリエン;リンパ球。このような機序がもし存在するとすれば,1)の反応系の関与する喘息はアトピー型喘息,2)は中高年発症型喘息,3)は所謂内因性喘息,3')は中高年発症型喘息として把握される可能性が強い。温泉療法は,気道清浄化作用および副腎皮質機能改善作用により,これらの反応系の発現を抑制する。
Abstract Alternative
Reactions for severe intractable asthma and actions of spa therapy on the reactions were discussed. Reactions participatng in onset mechanism of bronchial asthma were divided into three major groups. The first group comprises IgE-mast cell (eliciting phase), histamine (leukotrienes) (reactive phase; humoral phase), and lymphocytes-basophils-eosinophils (reactive phase; cellular phase). The second group comprises IgG-neutrophils, leukotrienes, and neutrophils-lymphocytes-macrophages. The third group is induced by non-IgE reactions, followed by PAF and eosinophils (with blood eosinophilia), and by leukotrienes and lymphocytes (without blood eosinophilia). If these reactions are really present and participate in onset mechanism of bronchial asthma, the first group could be observed in atopic asthma, the second one in late onset asthma, and the third one in so-called intrinsic asthma with blood eosinophilia and in late onset asthma without blood eosinophilia. Spa therapy has clearing actions of airway and improves function of adrenal glands in severe intractable asthma.
Keywords
気管支喘息 (Bronchial asthma)
難治性喘息 (lntractable asthma) 
アレルギー反応 (Allergic reaction)
温泉療法 (Spa therapy)
Published Date
1988-08
Publication Title
環境病態研報告
Publication Title Alternative
Papers of the Institute for Environmental Medicine, Okayama University Medical Scool
Volume
volume59
Publisher
岡山大学医学部附属環境病態研究施設, 岡山大学医学部附属病院三朝分院
Publisher Alternative
Institute for Environmental Medicine, Okayama University Medical Scool
Start Page
62
End Page
67
ISSN
09133771
NCID
AN10084718
Content Type
Departmental Bulletin Paper
language
日本語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc