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ID 19292
Eprint ID
19292
FullText URL
70_3951.pdf 5.43 MB
Title Alternative
Histological Study of Vital Organs under Experimental Hypothermia Part Ⅱ. Histological Studies of Vital Organs under Experimental Hypothermia with or without Cortisone & ACTH Administration
Author
Takagi, Shigeru
Abstract
Effects of pharmacological hibernation, induced hypothermia and administration of Cortisone & ACTH to the vital organ cells, were investigated histologically and the following results were obtained. 1) There were the most deleterious changes in the tissue cells under hypothermia without any anesthetics but the least under hypothermia with Phenothiazines. 2) The liver, kidney and lung were chiefly damaged, which were mainly circulatory, by body cooling. However, those changes of the organs were reduced by administration of Phenothiazine-derivatives, Cortisone or ACTH. 3) Histological changes were not increased by operative measure under hypothermia and pharmacological hibernation. 4) Glycogen in the livers, staining by PAS, decreased under hypothrmia but the decreasing was minimamized by administration of Phenothiazines, Cortisone and ACTH. 5) Decrease of nucleic acid in liver cells, by staining of nucleic acid, was noticed under hypothermia. 6) Various parenchymatous changes of the liver and kindney under hypothermia were thought to be caused by circulatory anoxia. 7) It was difficult to determine the limit of body cooling only by histological findings, but clarification of the cause of late death after hypothermia by histclogical findings was important. 8) Tolerance of rats to cold were increased by administration of Cortisone or ACTH, therefore these administration were very effective measures in order to save the lives under hypothermia.
Published Date
1958-11-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue11
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
3951
End Page
3964
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/11/70_11_3951/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma