脳のglucose代謝におよぼすamino酸の影響に関する研究 第2編 癲癇患者大脳皮質のglucose代謝およびそれにおよぼす種々のamino酸の影響について

The influences of the free amino-acids upon the glucose metabolism were investigated in the cerebral cortex removed from the epileptogenics and non-epileptogenics. Glucose metabolism decreased in the epileptogenic cerebral cortex, compared with the nonepileptogenic one. In the non-epileptogenic cerebral cortex, these free aminoacids accelerate the utilization of glucose, in the following order of γ-aminobutyric acid, aspartic acid, asparagine, glutamine, glutamic acid from the most to the least, while in the epileptogenic one in the order of aspartic acid, glutamic acid, asparagine, γ-aminobutyric acid and glutamine. These amino-acids have more pronounced function to accelerate the glucose metabolism in the epileptogenic brain than the nonepileptogenic.