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ID 18996
Eprint ID
18996
FullText URL
70_1795.pdf 1.17 MB
Title Alternative
Studies on the Pathogenesis of Idiopathic Thrombocytopenic Purpura Part Ⅰ. The Existence of Platelet Reducing Factor
Author
Awai, Kozi
Abstract
For the purpose of ascertaining the existence of platelet reducing factor in several materials obtained from 5 patients with I.T.P., those whom the author has studied, these materials were injected subcutaneously into rabbits. Moreover, additional experiments were made to investigate the effect of this factor upon the bone marrow. The results are as follows: 1) The patients' materials caused a marked reduction of more than 45% in the number cf platelets in the circulating blood when injected into rabbits. But materials obtained by same procedure from control human beings caused less than 30% reduction as compared with those before injection. 2) The existence of platelet reducing factor was found in patients' sera, urine, cerebrospinal liquor and spleen extracts. 3) 2 cases out of 5 were completely cured by splenectomy, and after operation this factor could not be found in their sera. 4) This factor is thermolabile and soluble in water. 5) Through the bone marrow streaming examination, this factor was found to act directly upon the bone marrow. 6) It is concluded that the continuous reduction in the number of platelets in these patients is the result of the inhibiting effect upon bone marrow by this factor produced from the spleen.
Published Date
1958-05-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue5
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1795
End Page
1813
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/5/70_5_1795/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma