焦性葡萄酸及びα-ケトグルタール酸に関する臨床的研究 第Ｉ編 血液・腰椎髄液・脳室髄液・蜘網膜下髄液中の焦性葡萄酸及びα-ケトグルタール酸について

1)著者は正常人並びに分裂病者の空腹安静時における,血中焦ブ並びにα-ケトグ量を測定して夫々次の様な結果を得た.イ)正常人 血中焦ブ量=0.84±0.05 mg/dl 血中α-ケトグ量=0.45±0.017 mg/dl ロ)分裂病者血中焦ブ量=0.79±0.039 mg/dl 血中α-ケトグ量=0.42±0.03 mg/dl 即ち分裂病者の血中両ケト酸平均値は,正常人のそれと略等しく,両者の間に有意の差を認めなかつた.2)器質的疾患を認めない分裂病者9例に脳手術(ロボトミー)を行い,略同時に夫々肘静脈血,腰椎髄液,脳室髄液を採取し,これらの焦ブ量,α-ケトグ量を測定し次の如き結果を得た.イ):血中焦ブ量=1.29±0.11 mg/dl 血中α-ケトグ量=0.59±0.10mg/dl ロ)腰椎髄液中焦ブ量=0.80±0.06 mg/dl: 腰椎髄液中α-ケトグ量=0.48±0.09 mg/dlハ):脳室髄液中焦ブ量=0.91±0.11 mg/dl :脳室髄液中α-ケトグ量=1.47±0.17 mg/dl 即ら焦ブ量濃度は血液,脳室髄液,腰椎髄液の順であり,α-ケトグ量は脳室髄液に尤も多く,次いで血液,腰椎髄液の順を示した.3)種々の条件の下で,肘静脈血,腰椎髄液,脳室髄液,脳表より採取した蜘網膜下髄液について両ケト酸を測定した所,蜘網膜下髄液中の両ケト酸は共に,腰椎髄液中のそれらと略等しい値を示した.

1. The author estimated the amount of pyruvate and α-ketoglutaric acid in the blood of normal persons and schizophrenic patients at rest with empty stomach and obtained the following results. Normal persons: In the case of normal persons the amount of pyruvate in blood gave the value, 0.84±0.05 mg/dl, whereas the amount of α-Ketoglutaric acid in blood proved to be 0.45±0.014 mg/dl. Schizophrenic patients: In the case of schizophrenia, the amount of pyruvate in blood yielded the value, 0.79±0.039 mg/dl, whereas the amount of α-ketoglutaric acid in blood proved to be 0.42±0.03 mg/dl. In other words, the average value of Pyruvate or α-ketoglutraic acid in schizophrenic patients and that in normal persons is approximately equal, showing no significant difference between the two. 2. After performing lobotomy on 9 cases of schizophrenic patients showing no disturbances in organ, blood from elbow vein, spinal fluid of lumbar region, and ventricle fluid were taken from these patients about the same time. The amounts of pyruvate and α-ketoglutaric acid in these fluids were measured; and the following results were obtained. The average value of pyruvate in blood=1.29±0.11 mg/dl; the average value of α-ketoglutaric acid in blood=0.59±0.10 mg/dl; the averge value of pyruvate in spinal fluid of lumbal regions =0.80±0.06 mg/dl; the average value of α-Ketoglutaric acid in spinal fluid of lumbal regions=0.43±0.09 mg/dl the average value of pyruvate in ventricle fluid=0.91±0.11 mg/dl; and the average value of α-ketoglutaric acid in ventricle fluid=1.47±0.17 mg/dl. Namely, the concentration of puruvate in these fluids has been found to be in the decreasing order of blood. ventricle fluid, and spinal fluid of lumbar regions; whereas the concentration of α-ketoglutaric acid has been found highest in ventricle fluid followed by that in blood spinal fluid of lumbar region in that order. 3. After extracting blood from elbow vein, spinal fluid from lumbar regions, ventricle fluid, and subarachnoid fluid from the surface of the brain under various conditions, the amounts of two acids contained in the subarachnoid fluid are about equal to those in the spinal fluid of lumbar region.