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ID 18801
Eprint ID
18801
FullText URL
Thumnail 70_471.pdf 501 KB
Title Alternative
Studies on the Pathogenesis of So-Called Banti's Disease Part Ⅱ. The Pathogenesis of Toxic Factor and its Influences upon the Iron and Copper Metabolisms in the Rabbits with Experimental Splenomegaly
Author
Miyai, Monjiro
Abstract
By injecting to normal rabbits the spleen extracts and sera of the rabbits with experimental splenomegaly, the author examined whether or not the toxic factor exists in such extracts and sera, and studied influences of the toxic factor upon the iron and copper metabolisms. The experimental results are described below. 1) A toxic factor was recognized to exist in the spleen and serum of the rabbits recei. ving the injections of methylcellulose, polyvinylalcohol and ovalbumin. 2) By the injection of the substances containing such a toxic factor to the normal rabbits, the value of serum iron became lower while that of copper higher. In studying the direction of action of the toxic factor mainly from the standpoint of the iron metabolism it has been found that despite the normal amount of depot iron, the serum iron decreased markedly. From this fact it is concluded that the anemia is caused by the inhibitory action of the toxic factor on the mobilization of depot iron with resultant interferance with the erythropoiesis in the bone marrow. 3) As mentioned above, the author believes beyond doubt to have confirmed for the first time the existence of a toxic factor in the spleen and serum in the rabbits with experimental hypersplenism and to have clarifed the active mechanism of the toxic factor.
Published Date
1958-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
471
End Page
477
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/2/70_2_471/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma