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ID 18780
Eprint ID
18780
FullText URL
Thumnail 70_267.pdf 655 KB
Title Alternative
Studies on the Immunization of Mice by Rickettsia tsutsugamushi Ⅰ: Studies on the influence of Antibiotics on Antigen Production in Mice Infected with Rickettsia tsutsugamushi
Author
Mitsui, Masao
Abstract
In respect to the dose of antibiotics and the period of administration, the author studied the influence of antibiotics on antibody production in mice infected with Rickettsia tsustugamushi. Chloramphenicol was used as the test antibiotic, and the antibody production was estimated by the Weil-Felix reaction and cellular figure of the ascites. The results were as follows: 1) When chloramphenicol was given to mice in the begginning period, 24 hours after inoculation of R. tsutsugamshi, the antisera of mice showed a positive agglutination reaction to 20× to 40× dilution. 2) When chloramphenicol was given to mice in the later period, 8 days after inoculation of R. tsutsugamushi, the antisera of mice showed a positive agglutination reaction to 80× to 120× dilution; a almost similar result in the control group of mice not given chloramphenicol, 3) The agglutination titer of antisera was a little higher in the mice continuously administered small doses of chloramphenicol than in those administered once a big dose. 4) In the group of mice given chloramphenicol in the begginning period, the cellular examination of the ascites revealed the increase of histiocytes and monocytes, and the slight decrese of serous cells and lymphocytes. In those given chloramphenicol in the later period, the increase of serous cells, lymphocytes as well as histiocytes was observed; nearly the similar cellular figure to those in mice receiving no chloramphenicol administration. From these results, it is considered that the administration of chloramphenicol has a very great influence on the production of antibody.
Published Date
1958-01-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume70
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
267
End Page
275
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/70/1/70_1_267/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma