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ID 18638
Eprint ID
18638
FullText URL
75_863.pdf 252 KB
Title Alternative
Studies of Convulsive Seizure Induced by Decadron Part 2 Studies of the Active Principle in Decadron Solution Effective in Inducing Convulsion
Author
Miyake, Shintaro
Abstract
Decadron solution for injection contains Dexamethasone-21-phosphate disodium, phenol, creatine, sodium citrate, sodium bisulfite, and sodium hydroxide. Therefore, the question of which substance of these is really effective for inducing convulsion, was investigated using mice. The results of the present studies were as follows: 1) Sodium citrate is the only substance in the Decadron solution which induces a convulsive seizure, similar to the Decadron Convulsion. 2) Erection the tail and tachypnea were observed in mice after administration of dexamethasone-21-phosphate disodium, but no convulsive seizure was recognized by dexamethasone-21-phosphate disodium itself. 3) In the case of simultaneously administered sodium citrate and Dexamethasone-21-phosphate, a Decadron type of convulsive seizure was observed. Therefore it was suggested that dexamethasone played the roll of an activat or for the convulsive seizure.
Published Date
1963-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume75
Issue
issue10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
863
End Page
867
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/75/10/75_10_863/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma