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ID 18525
Eprint ID
18525
FullText URL
Thumnail 72_593.pdf 5.5 MB
Title Alternative
Studies on Serological Reactions in Infectious Hepatitis Part 1. Studies on Auto-Liver-Antibody by Means of Colloidion Agglutination Reaction
Author
Hino, Masuo
Abstract
Studying the significance of serological diagnosis of auto-liver-antibody by means of collodion agglutination reaction, and also observing the production of the antibody following a few experimental liver impairments, the following results were obtained. 1. Positive titers of agglutination was determined as 128 times since the majority of the collodion agglutination reactions in the healthy individuals as well as in the cases of extrahepatic diseases, demonstrated below 128 times. 2. The positive titers of agglutination were noted in 73.9% on investigating the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction. 3. Observing the alteration of the auto-liver-antibody of infectious hepatitis by means of the collodion agglutination reaction and complement fixation reaction, it was noted that the collodion agglutination was more sensitive and that there were relatively high positive titers of the antibody in the acute stages (the second and third week) as well as in the chronic stages. 4. In the mutual relations between the quantities of the auto-liver-antibody detected by the agglutination reaction, the various clinical pictures and the laboratory data of infectious hepatitis, the reactive positive titer of agglutination have increased in proportion to serum colloid liver function tests, serum bilirubin (over 1 to 2 mg. %), positive urine urobilinogen reaction, and to hepato-splenomegalia. No evident correlation was noted between the reactive positive titers of agglutinations and the hemograms of infectious hepatitis, but in the group of the positive reaction fairy numbers of the cases with lymphocytosis and monocytosis were seen, compared with the group of negative ones. 5. Detecting the auto-liver-antibody by means of the collodion agglutination reaction have reflected the clinical pictures fairly well and would be a effective means for clarify the pathophysiology of hepatic diseases. 6. For the purpose of the investigation regarding the production of the auto-liver-antibody in case of aseptic liver impairment, experiments were performed such as aseptic squeezing, cauterization and ligation of the common bile duct. In these experiments, a production of the auto-liver-antibody was confirmed, in relatively early stages, by means of the collodion agglutination reaction.
Published Date
1960-01-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
593
End Page
600
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/2/72_2_593/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma