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ID 18515
Eprint ID
18515
FullText URL
Thumnail 72_515.pdf 2.82 MB
Title Alternative
Transaminase of Brain (Ⅱ) Effects of Psychotropic and Neurotropic Drugs on the Transaminase Activities
Author
Ono, Masaya
Abstract
ダイコクネズミ脳homogenateを用い,グルタミン酸-アスパラギン酸トランスアミナーゼ(GAT)活性に及ぼす18種の向精神薬,および3種の向神経薬の影響を測定した. 1. フエノチアジン系向精神薬は, Prochlorperazineを除く他の6種はいずれもGAT阻害を示し,阻害作用はChlorpromazineに最も強かつた. Chlorpromazine S-oxideはChlorpromazineに比してGAT阻害作用は著しく弱い. 2種のフエノチアジン系向神経薬はGAT活性に影響をみなかつた. 2. AzacyclonolはGAT阻害を示し, LSD-25は高濃度で阻害を示したが低濃度では影響を与えなかつた. 3. 中枢刺戟剤4種のうち, PipradrolとDMAEは促進, Methylphenidateは影響なく, Tofranilは阻害を示した. 4. バルビツール酸系睡眠剤AmobarbitalとPhenobarbital,非バルビツール酸系睡眠剤MethyprylonとGlutethimideは,すべて阻害を示した.しかるにバルビツール酸拮抗剤BemegrideはGATに無影響であつた.抗てんかん剤Primidoneは阻害を示した. 5. 実験に用いた中枢抑制剤13種のうち12種が阻害を示した. 6. GATに及ぼす作用において, ImipramineとChlorpromazineの類似, DiethazineやPromethazineとChlorpromazineとの差異を,化学構造における2個のN原子間の距離の一致と相異に対応すると考えた.
Abstract Alternative
Effects of 18 psychotropic and 3 neurotropic drugs were measured by the author on the glutamic-aspartic transaminase (GAT) activities in the rat brain homogenates. 1. Chlorpromazine, chlopromazine sulfoxide, acetylpromazine, levomepromazine, mepazine and perphenazine inhibited GAT, while prochlorperazine showed no effect. Both of diethazine and promethazine did not effect on GAT. 2. Pipradrol and dimethylaminoethanol activated GAT, while methylphenidate showed no effect. 3. Azacyclonol, amobarbital, phenobarbital, methyprylon, glutethimide and primidone were inhibitory in acion on GAT. 4. LSD-25 inhibited to GAT and bemegride did not effect on. 5. In the effect on GAT, similarities of imipramine to the phenothiazine derived depressants, or differences of diethazine and promethazine from other phenothiazine derivatives seemed to be causad due to the resemble or different distance between two nitrogen atoms.
Published Date
1960-01-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume72
Issue
issue2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
515
End Page
520
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/72/2/72_2_515/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma