このエントリーをはてなブックマークに追加
ID 18294
Eprint ID
18294
FullText URL
77_897.pdf 2.21 MB
Title Alternative
Studies on the Treatment of Chronic Hepatic Disorders with Fibroblast-inhibiting Agents Part 2. Effects of Chloroquine on the Experimental Chronic Hepatic Disorders of the Rabbit
Author
Yamana, Masatoshi
Abstract
Followings are the results of experimental studies on effects of chloroquine on the normal liver damages with carbon tetrachloride in rabbits. 1) It was noted that the animal treated with carbon tetrachloride showed prominent disturbance of liver functions and histological changes revealing extensive damage of the parenchymal cells and marked fibrosis in the liver. 2) The animal administered both chloroquine and carbon tetrachloride revealed normal liver function tests but had a slight degree of liver fibrosis, while the animal administered chloroquine alone revealed normal liver function without any fibrotic findings. However, the liver findings of the animal in combining treatment showed lesser pathological changes than those of the animal with carbon tetrachloride alone. 3) No influences were observed by long term administration of chloroquine to the normal animal on several laboratory examinations such as serum colloidal reactions, total serum protein and electrophoresis. Nor histological changes were noted in the normal liver, especially in its connective tissue. 4) It may be considered that fibroblast-inhibiting action of chloroquine has important roll to the prevention of chronic liver disturbance.
Published Date
1965-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
897
End Page
906
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/5-6/77_5-6_897/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma