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ID 18248
Eprint ID
18248
FullText URL
Thumnail 76_141.pdf 714 KB
Title Alternative
Studies on Treatment of Wakana Disease Ι. Anchylostomocidal effects of various drugs against hookworm larvae
Author
Yamamoto, Kuro
Abstract
The lung symptoms of Wakana disease are considered largely caused by the irritation of hookworm larvae migrated into the lung. With the purpose of killing the hookworm larvae, an anchylostomocidal experiment was conducted in vitro with chloroquine diphosphate, Stibnal, Mapharsen, Atebrin and emetin hydrochloride, and the following results were obtained. 1. At the in vitro concentrations comparable to those attained for adults, chloroquine diphosphate showed a most pronounced anchylostomocidal effect upon Anchylostoma caninum larvae followed by Stibnal, Mapharsen, Atebrin and emetin hydrochloride in that order. 2. The first three drugs found to be more effective against hookworm larvae in the above experiment were tested for the anchylostomocidal effect on Dubini larvae by adding the serum obtained from normal persons given intravenous injection of the adult dosage of these drugs. In this experiment, too, chloroquine diphosphate was most effective followed by Stibnal and Mapharsen. 3. From these results, it appears that chloroquine diphosphate, Stibnal and Mapharsen act quite effectively as auchylostomocides against hookworm larvae, and good therapeutic effects of these drugs can also be expected when used in Wakana disease. Of these three drugs, chloroquine diphosphate was most effective in both experiments and together with a possible high concentration of intravenously injected chloroquine diphosphate in the lung, the agent is considered to be a drug of choice in the treatment of Wakana disease.
Published Date
1964-03-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume76
Issue
issue1-3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
141
End Page
149
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/76/1-3/76_1-3_141/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma