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ID 18243
Eprint ID
18243
FullText URL
Thumnail 76_91.pdf 828 KB
Title Alternative
Studies on Leukemogenesis in RF Mice by Oral Administration of 20-methylcholanthrene. I. Co-leukemogenic Action of Croton Oil in the Induction of Leukemia by Oral Administration of 20-methylcholanthrene
Author
Ko, Itsuo
Abstract
1) Myelogenous and lymphocytic leukemias were observed among mice given orally three times a week 0.1-0.15cc of 0.8% 20-methylcholanthrene in olive oil by means of a needle catheter and concurrently painted in the back two times a week with 5% croton oil in benzene. 2) The incident of leukemias was 61.6% for myelogenous and 5.5% for lymphocytic leukemia with a total of 66.6%. On the other hand, mice receiving croton oil alone developed no leukemia. 3) Concurrent administration of 20-methylcholanthrene and croton oil reduced the average latent period required for the development of leukemia by about four weeks in comparison with that of 20-methylcholanthrene treatment alone. 4) From these results, it is concluded that croton oil is coleukemogenic, acting as a promoter in the 20-methylcholanthrene leukemogenesis in mice.
Published Date
1964-03-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume76
Issue
issue1-3
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
91
End Page
103
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/76/1-3/76_1-3_91/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma