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ID 18203
Eprint ID
18203
FullText URL
Thumnail 77_241.pdf 3.1 MB
Title Alternative
Clinical Significance of Serum N-Acetyl-β-Glucosaminidase Activity In Patients With Liver Diseases
Author
Tanaka, Akira
Abstract
Assays of the N-acetyl-β-glucosaminidase activity in sera and in liver tissues of patients with hepatic disorders were carried out by the method of Walker, using p-nitrophenyl-N-acetyl-β-glucosaminide as substrate. The results were as follows: 1. The normal activity of serum N-acetyl-β-glucosaminidase was 5.7 units in average. There was no significant difference in sex. 2. Serum N-acetyl-β-glucosaminidase activity showed a distinct increase in acute hepatitis, recurrent chronic hepatitis, precirrhosis and active cirrhosis. In active and inactive chronic hepatitis and inactive cirrhosis, the activity was slightly elevated. 3. In liver diseases the activity of serum N-acetyl-β-glucosaminidase changed independently of that of serum β-glucuronidase. 4. N-acetyl-β-glucosaminidase activity in serum showed a close correlation with that in liver tissues and such histological findings as "degeneration of liver cells", "Kupffer cell activation", "cell infiltration", "proliferation of connective tissue" in the liver. 5. The elevation of serum N-acetyl-β-glucosaminidase activity has a close relation to the proliferation of connective tissue in liver diseases, while it has a close relation to the acute destructive change such as degeneration and necrosis of the hepatic cells. 6. In obstructive jaundice and hepatic carcinoma, remarkably elevated activities of serum N-acetyl-β-glucosaminidase were observed.
Published Date
1965-01-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume77
Issue
issue1
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
241
End Page
249
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/77/1/77_1_241/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma