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ID 18174
Eprint ID
18174
FullText URL
Thumnail 80_1053.pdf 2.38 MB
Title Alternative
Immunological Studies on Rauscher Leukemia Ⅱ. Protection against Rauscher Leukemia with Rauscher Virus Vaccine. Changes of Serum Proteins
Author
Nagao, Tadami
Abstract
The serum protein were investigated by cellulose acetate electrophoresis in normal BALB/C mice, Rauscher leukemic mice, mice which were either protected or not protected with virus vaccine against virus challenge and mice which were given vaccine only. In leukemic mouse serum γ-globulin level increased slightly as the mice approached an initial stage of leukemia. In the advanced stage of leukemia there were a decrease of γ-globulin, α-globulin and albumin and an increase of β-globulin. Twenty days after virus inoculation, an abnormal fraction, not found in normal mice, was detected between α(2)-globulin and β-globulin fractions and markedly increased according to the progression of leukemia. The abnormal fraction was considered to be specific in Rauscher leukemia. Electrophoretic studies in mice which were protected against leukemia with vaccine revealed no such abnormal fraction but showed a marked increase of γ-globulin and β-globulin, probably due to a reaction of the host toward Rauscher leukemia. In mice which developed leukemia in spite of vaccination, the results of serum electrophoresis were the same as in the case of non-vaccinated leukemic mice. The change of serum fractions in mice which were treated with vaccine only showed an increase of γ-globulin and β-globulin.
Published Date
1968-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume80
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1053
End Page
1063
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/80/9-10/80_9-10_1053/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma