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ID 18107
Eprint ID
18107
FullText URL
Thumnail 79_865.pdf 869 KB
Title Alternative
Effects of Adrenal Glucocorticoids on Tissue Histamine Contents in Rats
Author
Kanai, Hiromu
Abstract
Male Wistar rats were received daily i. m. injection of hydrocortisone 10 mg/kg for 28 days. The histamine contents in the inner and outer layers of the skin, the majority of skin mast cells being contained in the former, began to decrease after 14 days, and in the jejunum decreased after 7 days, while there was an increase in histamine in the pyloric stomach after 7 days. In the control group receiving normal saline, no significant change was observed in these tissues during 28 days of injection except a slight increase in the pyloric stomach. The i. p. injection of sinomenine 50 mg/kg caused a marked (43%) reduction of histamine content in the inner layer of skin which completed within 60 minutes. In other tissues, the pyloric stomach and jejunum showed only a slight and transient reduction recovering before 24 hours. A single injection of hydrocortisone 10 mg/kg inhibited the histamine reduction by sinomenine in the inner layer of skin. But after repeated injection of hydrocortisone over 14 days such inhibition could no longer be observed on the histamine release due to sinomenine. In the adrenalectomized rats, the histamine contents of all these tissues were increased, most remarkable increase being in the pyloric stomach. There was no reduction of histamine in the skin after the injection of sinomenine despite appearance of a marked edema in the snout and pads.
Published Date
1967-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume79
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
865
End Page
877
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/79/11-12/79_11-12_865/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma