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ID 18008
Eprint ID
18008
FullText URL
79_359.pdf 2.24 MB
Title Alternative
Experimental Studies on the Influence of Surgical Intervention on the Metabolism of Reticuloendothelial System Ⅰ. A Study on Changes in the Metabolism of the RES under Anesthesia using Glycyrrhizin (59)Fe Colloid
Author
Fujisawa, Masahiko
Abstract
For the purpose to study changes in the metabolism of RES in vivo under anesthesia over a long period a series of experimental observations were conducted with dogs by means of Glycyrrhizin (59)Fe-colloid method and the following results were obtained. 1. It was found that to the dog under anesthesia the phagocytosis of the RES is clearly inhibited, and with the use of Isozole it is slightly inhibited, while deep anesthesia such as combination anesthesia and low body temperature anesthesia distinctly affects the phagocytic function of the RES. 2. On the other hand, in the study of the hemoglobin synthesis which reflects the metabolic function of the RES, by means of fractionation of hermin iron and non-hemin iron in erythrocytes it was demonstrated that the hemoglobin synthesis is clearly inhibited by anesthesia and deep anesthesia inhibits the synthesis to a greater extent. 3. Simultaneous observations of the total organic iron, hemosiderin, ferritin fractions revealed that under anesthesia the retension of hemosiderin is increased, ferritin is decreased, and the ratio of hemosiderin to ferritin is lessened, suggesting that there develops a retension phenomenon in the RES. 4. The metabolic function of the RES is markedly inhibited by the low body temperature anesthesia at 27℃ to 28℃ but along with the lapse of time there develops an adaptation-recovery phenomenon and the metabolic function is inhibited more markedly rather than phagocytosis but it does not reach the stage of arresting the reaction. These findings clearly demonstrate that the Glycyrrhizin (59)Fe colloid method is a superior one for examining the functions of the RES to the classical method available. Further, in the investigation of the RES by this method it has been suggested that the function of RES is less inhibited by shallow anesthesia while by the deep anesthesia its inhibition is greater, and that under the low body temperature anesthesia more of the primeval function of the RES is maintained, thus rendering many useful criteria of clinical importancs.
Published Date
1967-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume79
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
359
End Page
372
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/79/3-4/79_3-4_359/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma