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ID 17944
Eprint ID
17944
FullText URL
79_109.pdf 1.92 MB
Title Alternative
Studies on an Effect of ACTH on Brain Tissue Part Ⅰ.Clinical observations and experimental studies on dogs removed of adrenal glands
Author
Takahara, Jiro
Abstract
The direct effect of ACTH on brain tissue not by way of adrenal glands is suggest by the fact that ACTH has a remarkable therapeutic effect on vairous diseases of nervous system such as japanese encephalitis. The first part of the present report is concerned with statistical observation of therapeutic effect of ACTH on patients with nervous diseases. 1) ACTH was effective in 70 per cent. The effect was especially marked in Parkinson's syndrome, japanese encephalitis and chorea minor. 2) As for symptoms, disturbance of consciousness, fever, involuntry movements and mucle rigidity were successfully treated by ACTH. 3) In intracranial bleeding and thrombosis too, ACTH showed a good effect on loss of consciousness, motor disturbance and dysarthria in a decreasing order. The second part is concerned with observation of therapeutic effect of ACTH on brain edema of adrenectomized dogs. Degree of edema is calculated by the amount of RIHSA measured in the brain. 1) In the control, index of brain edema (amount of isotope of brains cortex of the thrombosed side/that of the contralateral normal cortex) was 15.6 2) In dogs removed of adrenal cortex & treated by ACTH, index of brain edema was 6.4. The above results indicate that ACTH has a dirct effect, not by way of adrenal cortex. It is clarified, however, whether this effect is a direct on brain tissue or by an enhancement of coricosteroid effect.
Published Date
1967-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume79
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
109
End Page
118
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=79&noissue=3-4&startpage=109
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma