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ID 17689
Eprint ID
17689
FullText URL
Thumnail 88_1039.pdf 840 KB
Title Alternative
Studies on treatment in lung cancer Part Ⅱ. Studies on cellular immunity in lung cancer: Changes in cellular immune responses of patients treated with chemotherapeutic and streptococcal agents
Author
Fujii, Masafumi
Abstract
Cellular immunity in lung cancer was studied by means of lymphocyte transformation by phytohemagglutinin (PHA), purified protein derivative (PPD) skin test, absolute counts of peripheral lymphocytes and leucocyte migration inhibition test. The lymphocyte transformation by PHA was reduced in lung cancer patients in comparison with healthy controls, and correlated with the disease stage, but not with the histology type. The lymphocyte transformation became further depressed by cancer chemotherapy. PPD skin reaction or absolute counts of peripheral lymphocytes did not correlate with the disease stage. However, all the three tests correlated with the disease stage. Therefore, these tests appeared to be general indices of the immunologic status. Inhibition of leucocyte migration was demonstrated in about a half of the patients with lung cancer, but not in patients with other cancers or infectious lung diseases or in healthy controls. These findings suggest the presence of tumor-associated antigens in lung cancer. Concerning the effect of the streptococcal agent, OK-432, enhancement of the function of lymphocyte was observed in the parameters such as lymphocyte transformation by PHA, PPD skin test and leucocyte migration inhibition test. In addition, OK-432 yielded a longer survival in lung cancer patients when used in combination with chemotherapy than with chemotherapy alone.
Published Date
1976-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1039
End Page
1054
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/11-12/88_11-12_1039/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma