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ID 17631
Eprint ID
17631
FullText URL
Thumnail 88_545.pdf 949 KB
Title Alternative
Immunological studies on chronic myelogenous leukemia Part Ⅱ. Humoral immunity in chronic myelogenous leukemia
Author
Chen, Po-min
Abstract
To study the humoral reactivity in chronic myelogenous leukemia (CML), the author examined immunoglobuline levels, immune adherence hemagglutination test (IAHA) and lymphocytotoxicity test on the 24 patients admitted to our clinic. The following data were obtained: 1) The 19 patients, whose serum immunoglobuline levels were examined, were all within normal range with mean values of IgA 203±74mg/dl, IgG 1463±275mg/dl and IgM 182±67mg/dl. 2) IAHA was positive in 4 of 24 patients (16.7%) and the reactivity was correlated with the number of peripheral leukemic cells used as antigen; it was positive in 3 of 9 patients (33.3%) with leukemic cells over 4×10(4)/μ 1, but in only one of 15 patients (6.7%) with leukemic cells below 4×10(4)/μ 1. The IAHA test was also correlated with the disease state; none of 4 patients (0%) during blastic crisis of CML showed a positive reaction to their own leukemic cells. 3) Sera from 12 of 17 patients (70.6%) showed a positive lymphocytotoxicity to normal lymphocytes. In its correlation with the disease state, it was positive in 8 of 13 patients (61.5%) during remission and in all the patients (100%) during relapse. From these results it could be concluded that humoral immunity in CML is not so impaired through the clinical course except for blastic crisis.
Published Date
1976-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
545
End Page
551
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/7-8/88_7-8_545/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma