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ID 17612
Eprint ID
17612
FullText URL
85_505.pdf 621 KB
85_e1.pdf 104 KB
Title Alternative
Study on the Treatment of Malignant Tumors with Fibroblast-Inhibiting Agent Part 1. Effect of Phytonadione on Liver Catalase Activity of Animals Bearing Malignant Tumors
Author
Shirai, Kouichi
Abstract
Followings are the results derived from the treatment of malignant tumors of animals with the fibroblast-inhibiting agent such as phytonadione based on the unique idea of ours. 1) No effect was observed on the catalase activity of liver tussue homogenate of normal healthy mice by the direct addition of excessive doses of phytonabione. 2) No change was observed in the liver catalase activity of normal mice abministrated 50mg/kg of phytonadione. 3) Inhibition of decreasing liver catalase activity was observed at two weeks after abministration of phytonadione in mice bearing sarcoma-180 ascites and subcutaneous tumors. 4) No inhibition of decreasing liver catalase activity was observed at one week after administration of 50mg/kg of phytonadione in mice bearing Ehrlich subcutaneous cancer. 5) With the combination use of phytonadione and one of the fibroblastinhibiting agents, chloroquine, a more remarkable inhibiting effect of decreasing liver catalase activity was observed than with a single abministration of chloroquine in mice bearing asrcoma-180 ascites tumor. 6) Remarkable carcinostatic effect was observed with the combination use of mitomycin-C and phytonadione than with the single administration of mitomycin-C.
Published Date
1973-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
505
End Page
516
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/9-10/85_9-10_505/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma