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ID 17593
Eprint ID
17593
FullText URL
Thumnail 85_363.pdf 460 KB
Title Alternative
Studies on Guanidino Compounds in Brain by Automatic Liquid Chromatography
Author
Hosotani, Mitsuhiko
Abstract
1. Guanidino compounds, taurocyamine, glycocyamine, α-N-acetyl-L-arginine, β-guanidinopropionic acid, γ-guanidino-β-hydroxybutyric acid, γ-guanidinobutyric acid, γ-hydroxyarginine, arginine and γ-guanidinobutyramide, were analysed by the automatic guanidino compound analysing system, based on liquid chromatography with an ion exchange resine LCR-1 (or Aminex A-5) column and Sakaguchi reaction. 2. The concentrations of taurocyamine, glycocyamine, γ-guanidinobutyric acid and arginine in rodent brain tissue were determind. On the other hand, five unknown peaks with positive Sakaguchi reaction were observed in the rabbit brain. 3. Guanidino compounds level in liver, kidney, serum and urine of rabbit were determined and compeared with in brain. 4. It was observed that γ-guanidinobutyric acid in the rabbit brain was increased, and on the contrary, taurocyamine, glycocyamine and arginine were decreased during convulsion induced by Metrazol injection. 5. Arginine and taurocyamine levels in the El-mouse were tended to increase atfer having the convulsive disposition.
Published Date
1973-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
363
End Page
371
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/7-8/85_7-8_363/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma