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ID 17572
Eprint ID
17572
FullText URL
Thumnail 88_209.pdf 1.21 MB
Title Alternative
Metabolism of 4-amino-3-hydroxybutanoic acids in the mouse organs and their inhibitory effects on penicillin-induced spike activity of the cat cerebral cortex and on electrical activity of an identified snail giant neurone
Author
Katayama, Yasuto
Abstract
1) 1-(14)C labelled (3R)-(-)-4-amino-3-hydroxybutanoic acid (l-GABOB) and (3S)-(+)-4-amino-3-hydroxybutanoic acid (d-GABOB) were prepared from their racemic compound using camphor-10-sulfonic acid. These optical isomers were administered at the dose of 5.6μCi(1mg) to mice intraperitoneally and observed that l-GABOB was uptaken more rapidly into blood and organs, and metabolized more rapidly in the liver and kidney than d-GABOB, and that l-GABOB could penetrate significantly into the brain, while d-GABOB could hardly do it. 2) These substances in the concentration of 10(-3)M were topically applied on the epileptogenic focus of the cat cerebral cortex induced by potassium benzyl penicillin. As the results of the experiment, no more spike was observed several minutes after l-GABOB administration (n=6, all cases). On the contrary, the optical isomer, d-GABOB, showed a very weakly effect (Spike counts were reduced to 64.5±3.8%, n=6, P<0.05), and racemic GABOB moderately (Spike counts were reduced to 16.4±5.5%, n=6, P<0.05). 3) These substances were applied on the giant neurone, identified subesophageal ganglia of the african giant snail (Achatina fulica Ferussac) by bath-application method and microdropapplication method. As the results of the experiment, it was clarified that l-GABOB inhibited more strongly the electrical activity of the neurone than d-GABOB did it.
Published Date
1976-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume88
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
209
End Page
221
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/88/3-4/88_3-4_209/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma