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ID 17552
Eprint ID
17552
FullText URL
Thumnail 85_129.pdf 413 KB
Title Alternative
Effects of Irradiation on Lipid Peroxidation in Rat Organs.Part Ⅰ. Effects of whole body irradiation on lipid peroxide formation in rat organs.
Author
Watanabe, Setsuo
Abstract
After the whole body X-irradiation (650R) of rats, the lipid peroxide formation of various organs were estimated by the TBA reaction, and the results are presented as follows: (1) In TBA reaction tests on the lipid peroxidation in the liver, heart, spleen and kidney with homogenates being incubated, the TBA value were slightly high with endogenous homogenates, but on the addition of Fe(++) the reaction was further accelerated markedly. With liver and kidney that showed a high reaction on addition of Fe(++), the reaction was similarly accelerated on addition of ascorbic acid, but with heart and spleen the reaction at initial stage did not show any significant difference from that of the group without any addition. (2) In every organ from the irradiated animal the activity of lipid peroxide formation was greater than that in organs from non-irradiated control animals. (3) TBA value in the group added with Fe(++) were higher than those in the group without any addition, suggesting that X-irradiation greatly the lipid peroxidation in organs. (4) Change in the acceleration of lipid peroxidation accompanying the irradiation appears as a shortening of reaction-induction time. (5) Radioactivity-dose dependent change can be observed only in the liver, and the time-lapse change after irradiation can also observed only in the liver. (6) These results suggest that the lipid peroxidation following the whole body X-irradiation shows a significant change primarily in the liver.
Published Date
1973-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
129
End Page
136
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/3-4/85_3-4_129/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma