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ID 17532
Eprint ID
17532
FullText URL
Thumnail 85_35.pdf 7.71 MB
Title Alternative
Study on the Intoxication by Organic Chloride Preparations for Agricultural Uses. Part Ⅰ. A simplified detection of organic chloride preparations in peripheral blood and its application to clinical use
Author
Nawa, Hideaki
Abstract
According to the statistics by the Ministry of Health on toxications due to drugs for agricultural uses, we have had incidents by organic chloride compounds for many years. In future, there is also a possibility to encounter chronic intoxications by the above compounds. We have relied on solely a close observation on clinical manifestations for its diagnosis. Understandably, there has been no proper treatments established up to now. Therefore, it is a very urgent demand in our community to establish the most reliable method detecting organic chloride substance. The author have tried to devise a simplified method to detect organic chloride substance, as quick as possible in peripheral blood, using an electron capture detector. Its principle was based on gas-chromatography. Results 1) It takes approximately one hour with petroleum-ether to extract organic chlorides in peripheral blood. This is a simplified and speedy method as compared to a conventional way which needs a complicated clean-up. 2) A minimal concentration of organic chlorides to be detected is 0.008ppm for Dieldrin, 0.003ppm Aldrin, 0.02ppm p,p'-DDT and 0.003ppm γ-BHC, indicating a significantly sensitive method. 3) It is feasible to extract various organic chlorides separately by combining several columns in a gas-chromatograph, i.e., 1.5% SE-30, 10% DC-200+15% QF-1 and 1.5% OV-17. The author, thus, has been able to produce an evidence that the above method is extremely useful for diagnosing the intoxication by organic chlorides. Using this method, a part of the dynamics in the intoxicated patients has been also clearified.
Published Date
1973-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
35
End Page
45
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_35/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
File Version
publisher
Refereed
True
Eprints Journal Name
joma