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ID 17531
Eprint ID
17531
FullText URL
Thumnail 85_23.pdf 7.22 MB
Title Alternative
Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅳ. Effects of chloroquine on human tumors
Author
Shibuya, Koichi
Abstract
An fibroblast-inhibiting agent, chloroquine was administered to cancer patients and the following results were obtined. 1) Chloroquine diphosphate and chloroquine diorotate was given to 54 patients with histologically proven cancers of these it was effective in 38, non-effective in 15 and unknown in 1. The drug was particularly effective in lung cancer (12/13) and bladder cancer (6/8). In effective cases, there were alleviation of pain and improvement anemia, blood sedimention rate, serum protein and serum iron. Tumor regression often occurred and histologically, tendency of tumor necrosis and inhibition of interstitial connective tissue were observed. 2) The side effects of chloroquine were silght and 8 of 54 patients treated showed slight gastrointestinal, neurological or eye complaints. Hematopoiesis was not impaired. 3) The mechanism of action of this agent seems to be in the inhibition of cancer stromal connective tissue, anti-inflamatory and constiutional humoral effects. 4) Therefore, the indication of this drug includes inoperable cases, pre-and post-operative cases, especially in those who failed to respond to ordinary anti-cancer agents.
Published Date
1973-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
23
End Page
34
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_23/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma