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ID 17529
Eprint ID
17529
FullText URL
Thumnail 85_9.pdf 1.17 MB
Title Alternative
Studies on the treatment of malignant tumors with fibroblast-inhibiting agents Part Ⅱ. Effects of chloroquine on tumor-bearing animals (Bashford cancer)
Author
Shibuya, Koichi
Abstract
Chloroquine diphosphate, as demonstrated to be a fibroblast-inhibiting agent, was employed in an attempt to suppress the growth of cancer indirectly by inhibiting the interstitial connective tissue of cancer. Bashford cancer which is relatively rich in the interstitium was tested with this agent and the following results were obtained. 1) Chloroquine diphosphate clearly retarded the growth of Bashford cancer. The daily intraperitoneal dose of 25mg/kg was more effective than 10mg/kg. 2) The life span of the tumor-bearing animals was slightly prolonged as compared to controls. 3) The above data were supported by the collateral experimental results; an increase of tumor tissue necrosis as shown by histological and histochemical studies, a decrease of connective tissue elements and acid mucopolysaccharide, inhibition of lowering of liver catalase activity, and a decrease of iron in the tumor and other organs.
Published Date
1973-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume85
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
9
End Page
14
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_9/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma