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ID 17511
Eprint ID
17511
FullText URL
87_1023.pdf 1.97 MB
Title Alternative
Ⅱ. Histological Studies on Experimental Allergic Hepatitis with Appraisal of Mononuclear Cells in its Development
Author
Hirata, Hiroaki
Abstract
ヒトの肝炎の進展,慢性化の過程において,肝のグリソン鞘に浸潤している単核細胞がいかなる役割を果しているかを究明する一つの試みとして, complete Freund's adjuvant添加同種肝抗原でC57Blマウスを長期感作して実験的アレルギー性肝炎を作成し,感作C57Blマウスの脾およびリンパ節より感作リンパ球を分離し,レントゲン全身照射後の同系マウスに移入し,受動転嫁実験を実施した.その結果,対照群に比して,39例中15例に肝の組織変化を認めた.そのうち,早期すなわち移入後2~3日目に発生した広範な凝固壊死を14例中3例に,やゝ遅れた時期すなわち移入後5~8日目に発生したpiecemeal necrosisを主体とする変化を25例中2例に認め,それらの変化は感作リンパ球による肝細胞性壊死であることを強く示唆した.以上の肝の組織変化はヒトのウイルス性肝炎の組織所見に類似しており, B型肝炎発症における主要因の1つ,すなわちHB抗原感作リンパ球の果す意義にも関連して重要な実験成績であると考えた.
Abstract Alternative
In an attempt to evaluate the significance of mononuclear cells in the experimental allergic hepatitis which was previously studied, lymphocytes from inbred strain C(57) BL mice with the hepatitis was passively transfered into x-ray irradiated isologous mice. Early histological changes in the liver of the recipient mice consisted of an extensive coagulation necrosis on the 2nd or 3rd day after the transfer, and delayed changes occurring on the 7th to 10th post-transfer day included a marked infiltration of mononuclear cells in the portal areas, various types of liver cell necrosis and degeneration, a mononuclear cell infiltration in the sinusoid as well as an activation of the Kupffer cells as compared with control groups. These histological changes, however, were transient and subsided in 2 to 3 weeks post to the transfer of the cells. There was no tendency to the development of a feature of chronic hepatitis. The present experiment indicated that the passive transfer of sensitized lymphocytes obtained from mice with the experimental allergic hepatitis made by the previous experiment produced an allergic hepatitis comprising a coagulation necrosis and others in isologous mice, but this hepatitic change was transient and by no means transformed to a chronic status similar to a human chronic hepatitis as in the previous experiment.
Published Date
1975-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1023
End Page
1032
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/11-12/87_11-12_1023/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma