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ID 17436
Eprint ID
17436
FullText URL
Thumnail 87_549.pdf 1.51 MB
Title Alternative
Studies on the Infection of Human Cultured Leukocytes with Murine Rauscher Leukemia Virus Ⅰ. Persistent Dual Infection of Human Lymphoblastoid Cells with EB Virus and C Type Virus
Author
Hayashi, Takehiko
Abstract
An EB virus-carrying lymphoblastoid cell line established from peripheral blood of a patient with SMON was super-infected in vitro with murine Rauscher leukemia virus. Since then, the cell line has been dually infected with both viruses for more than 1.5 years, as repeatedly demonstrated by the presence of herpes type virus particles and C type virus particles. The C type virus particles liberated from the human cultured leukocytes were no longer leukemogenic when inoculated into otherwise susceptible BALB/c mice, but this procedure rendered them considerably resistant to challenge infection with leukemogenic Rauscher leukemia virus that had been maintained by passage through BALB/c mice. The infectivity of the human cell-derived C type virus to other lymphoblastoid cell lines established from different patients and to primary BALB/c mouse embryo cells could not be demonstrated by the method employed. The implication of these findings is discussed in the light of possible viral etiology of human malignancy.
Published Date
1975-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
549
End Page
556
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/5-6/87_5-6_549/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma